{"id":4735,"date":"2025-05-27T12:59:51","date_gmt":"2025-05-27T03:59:51","guid":{"rendered":"https:\/\/indna.co.kr\/?page_id=4735"},"modified":"2025-08-11T16:20:22","modified_gmt":"2025-08-11T07:20:22","slug":"pan-methylation-service","status":"publish","type":"page","link":"https:\/\/indna.co.kr\/?page_id=4735","title":{"rendered":"BeLight\u2122 Pan Cancer Gene and Methylation Panel \uc11c\ube44\uc2a4"},"content":{"rendered":"\t\t
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BeLight\u2122 Pan Cancer Gene and Methylation Panel \uc11c\ube44\uc2a4<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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BeLight\u2122 Pan Cancer Gene and Methylation Panel \uc11c\ube44\uc2a4<\/b><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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BeLight\u2122 Pan Cancer Gene and Methylation Panel<\/b>\uc740 <\/b>132\uac1c \uc720\uc804\uc790 \uc804\uccb4 \uc5d1\uc190(exon), openPBTA 64\uac1c \uc720\uc804\uc790 \ud56b\uc2a4\ud31f, custom selected 58\uac1c \uc720\uc804\uc790 \ud56b\uc2a4\ud31f, 23\uac1c fusion \uc720\uc804\uc790, 33\uac1c CNV, MSI \ubd84\uc11d\uc774 \ubaa8\ub450 \uac00\ub2a5\ud558\ub3c4\ub85d \uc124\uacc4\ub41c Gene Panel\uacfc, Pediatric Brain Tumor(\uc18c\uc544 \ub1cc\uc885\uc591) \ud2b9\uc774\uc801 Methylation Sites\uac00 \ud3ec\ud568\ub41c Pan Cancer Methylation Panel\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.\u00a0<\/span><\/span><\/span>\ubcf8 \ud328\ub110\uc740 \uadf9\uc18c\ub7c9\uc758 \uc870\uc9c1 \ub610\ub294 cfDNA \uc2dc\ub8cc\ub9cc\uc73c\ub85c\ub3c4 Genetic Alteration(\uc720\uc804\uc801 \ubcc0\uc774)\uc640 Methylation \uc815\ubcf4\ub97c \ub3d9\uc2dc\uc5d0 \ubd84\uc11d\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/b><\/p>

BeLight<\/b>\u2122<\/span>\uc758 \uc11c\ube44\uc2a4\ub294 \ubcf8 \ud328\ub110\uc744 \uadf8\ub300\ub85c \ud65c\uc6a9\ud558\uc2e4 \uc218 \uc788\uc73c\uba70, \uc5f0\uad6c\uc790\ub2d8\uc758 \uc5f0\uad6c \ubaa9\uc801\uc5d0 \ub530\ub77c \uc6d0\ud558\ub294 \uc720\uc804\uc790 \ubc0f \uba54\ud2f8\ud654 \ubd80\uc704\ub97c \ubc18\uc601\ud55c Custom \ud328\ub110 \uc81c\uc791, \ub77c\uc774\ube0c\ub7ec\ub9ac \uad6c\ucd95 \ubc0f \uc2dc\ud000\uc2f1 \uc11c\ube44\uc2a4\ub3c4 \uc81c\uacf5\ud574\ub4dc\ub9bd\ub2c8\ub2e4.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\ubcf8 \uc11c\ube44\uc2a4\ub294 2025\ub144 scientific report\uc5d0 \ub4f1\uc7ac\ub41c \ub2f9\uc0ac\uc758 \uc5f0\uad6c \ub17c\ubb38\uacfc \ub3d9\uc77c\ud55c workflow\ub97c \uc0ac\uc6a9\ud569\ub2c8\ub2e4.\u00a0<\/b><\/span><\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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https:\/\/www.nature.com\/articles\/s41598-025-91537-4<\/a><\/b><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Gene List for Gene Panel(894Kb,\u00a0<\/span><\/span><\/span>*\uc18c\uc544\ub1cc\uc554 methyl panel\uc740 \ubcc4\ub3c4 \ubb38\uc758 \ubc14\ub78d\ub2c8\ub2e4.)<\/span><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Gene Symbol<\/th>All Exons<\/th>CNVs<\/th>DNA Fusions<\/th>Gene Symbol<\/th>All Exons<\/th>CNVs<\/th>DNA Fusions<\/th>Gene Symbol<\/th>All Exons<\/th>CNVs<\/th>DNA Fusions<\/th>Gene Symbol<\/th>All Exons<\/th>CNVs<\/th>DNA Fusions<\/th>\n<\/tr>\n<\/thead>\n
ABL1<\/td>O<\/td>–<\/td>–<\/td>EED<\/td>O<\/td>–<\/td>–<\/td>JAK1<\/td>O<\/td>–<\/td>–<\/td>PDGFRB<\/td>O<\/td>O<\/td>–<\/td>\n<\/tr>\n
AKT1<\/td>O<\/td>–<\/td>–<\/td>EGFR<\/td>O<\/td>O
\r\n<\/td>		O
\r\n<\/td>		JAK2<\/td>O<\/td>O<\/td>–<\/td>PIK3C2B<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
AKT2<\/td>O<\/td>O<\/td>–<\/td>EP300<\/td>O<\/td>–<\/td>–<\/td>JAK3<\/td>O<\/td>–<\/td>–<\/td>PIK3CA<\/td>O<\/td>O<\/td>–<\/td>\n<\/tr>\n
AKT3<\/td>O<\/td>–<\/td>–<\/td>EPCAM<\/td>O<\/td>–<\/td>–<\/td>KDM6A<\/td>O<\/td>–<\/td>–<\/td>PIK3R1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
ALK<\/td>O<\/td>O<\/td>O<\/td>ERBB2<\/td>O<\/td>O
\r\n<\/td>		–<\/td>KEAP1<\/td>O<\/td>–<\/td>–<\/td>PIK3R2<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
APC<\/td>O<\/td>–<\/td>–<\/td>ERBB3<\/td>O<\/td>O
\r\n<\/td>		–<\/td>KIT<\/td>O<\/td>O<\/td>–<\/td>POLD1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
ARAF<\/td>O<\/td>–<\/td>–<\/td>ERBB4<\/td>O<\/td>–<\/td>–<\/td>KRAS<\/td>O<\/td>O<\/td>–<\/td>POLE<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
ARID1A<\/td>O<\/td>–<\/td>–<\/td>ESR1<\/td>O<\/td>O
\r\n<\/td>		–<\/td>MAP2K1<\/td>O<\/td>–<\/td>–<\/td>PPARG<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
ARID2<\/td>O<\/td>–<\/td>–<\/td>ETV1<\/td>O<\/td>–<\/td>O
\r\n<\/td>		MAP2K2<\/td>O<\/td>–<\/td>–<\/td>PRKCI<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
ASXL1<\/td>O<\/td>–<\/td>–<\/td>ETV4<\/td>O<\/td>–<\/td>O
\r\n<\/td>		MDM2<\/td>O<\/td>O<\/td>–<\/td>PTCH1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
ATM<\/td>O<\/td>O<\/td>–<\/td>ETV6<\/td>O<\/td>–<\/td>O
\r\n<\/td>		MDM4<\/td>O<\/td>O<\/td>–<\/td>PTEN<\/td>O<\/td>O<\/td>–<\/td>\n<\/tr>\n
AXIN1<\/td>O<\/td>–<\/td>–<\/td>EWSR1<\/td>O<\/td>–<\/td>O
\r\n<\/td>		MET<\/td>O<\/td>O<\/td>–<\/td>RAC1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
AXL<\/td>O<\/td>–<\/td>–<\/td>EZH2<\/td>O<\/td>–<\/td>–<\/td>MLH1<\/td>O<\/td>–<\/td>–<\/td>RAF1<\/td>O<\/td>O<\/td>–<\/td>\n<\/tr>\n
BAP1<\/td>O<\/td>–<\/td>–<\/td>FAT1<\/td>O<\/td>–<\/td>–<\/td>MTOR<\/td>O<\/td>–<\/td>–<\/td>RB1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
BARD1<\/td>O<\/td>–<\/td>–<\/td>FBXW7<\/td>O<\/td>–<\/td>–<\/td>MYC<\/td>O<\/td>O<\/td>–<\/td>RET<\/td>O<\/td>O<\/td>O<\/td>\n<\/tr>\n
BCL2L11<\/td>O<\/td>–<\/td>–<\/td>FGFR1<\/td>O<\/td>O
\r\n<\/td>		–<\/td>MYCN<\/td>O<\/td>O<\/td>–<\/td>RHOA<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
BCR<\/td>O<\/td>–<\/td>O<\/td>FGFR2<\/td>O<\/td>O
\r\n<\/td>		O
\r\n<\/td>		NAB2<\/td>O<\/td>–<\/td>O<\/td>ROS1<\/td>O<\/td>–<\/td>O<\/td>\n<\/tr>\n
BRAF<\/td>O<\/td>O<\/td>O<\/td>FGFR3<\/td>O<\/td>O
\r\n<\/td>		O
\r\n<\/td>		NF1<\/td>O<\/td>–<\/td>–<\/td>SETBP1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
BRCA1<\/td>O<\/td>O<\/td>–<\/td>FGFR4<\/td>O<\/td>O
\r\n<\/td>		–<\/td>NFE2L2<\/td>O<\/td>–<\/td>–<\/td>SETD2<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
BRCA2<\/td>O<\/td>O<\/td>–<\/td>FLT3<\/td>O<\/td>–<\/td>–<\/td>NOTCH1<\/td>O<\/td>–<\/td>–<\/td>SMAD4<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CCND1<\/td>O<\/td>O<\/td>–<\/td>GNA11<\/td>O<\/td>–<\/td>–<\/td>NOTCH2<\/td>O<\/td>–<\/td>–<\/td>SMARCA4<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CD274<\/td>O<\/td>–<\/td>–<\/td>GNAQ<\/td>O<\/td>–<\/td>–<\/td>NOTCH3<\/td>O<\/td>–<\/td>–<\/td>SMARCB1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CD74<\/td>O<\/td><\/td>O<\/td>GNAS<\/td>O<\/td>–<\/td>–<\/td>NRAS<\/td>O<\/td>O<\/td>–<\/td>SMC3<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CDK12<\/td>O<\/td>–<\/td>–<\/td>HGF<\/td>O<\/td>–<\/td>–<\/td>NRG1<\/td>O<\/td>O<\/td>–<\/td>SMO<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CDK4<\/td>O<\/td>O<\/td>–<\/td>HRAS<\/td>O<\/td>–<\/td>–<\/td>NTRK1<\/td>O<\/td>–<\/td>O<\/td>STAT3<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CDKN2A<\/td>O<\/td>–<\/td>–<\/td>IDH1<\/td>O<\/td>–<\/td>–<\/td>NTRK2<\/td>O<\/td>–<\/td>O<\/td>STK11<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CHEK2<\/td>O<\/td>O<\/td>–<\/td>IDH2<\/td>O<\/td>–<\/td>–<\/td>NTRK3<\/td>O<\/td>–<\/td>–<\/td>TERT<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CREBBP<\/td>O<\/td>–<\/td>–<\/td>IGF1R<\/td>O<\/td>–<\/td>–<\/td>NUTM1<\/td>O<\/td>–<\/td>O<\/td>TFE3<\/td>O<\/td>–<\/td>O<\/td>\n<\/tr>\n
CRKL<\/td>O<\/td>–<\/td>–<\/td>IGF2<\/td>O<\/td>–<\/td>–<\/td>PALB2<\/td>O<\/td>–<\/td>–<\/td>TMPRSS2<\/td>O<\/td>–<\/td>O<\/td>\n<\/tr>\n
CTNNB1<\/td>O<\/td>–<\/td>–<\/td>IL7R<\/td>O<\/td>–<\/td>–<\/td>PAX3<\/td>O<\/td>–<\/td>O<\/td>TP53<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
CUL3<\/td>O<\/td>–<\/td>–<\/td>INPP4B<\/td>O<\/td>–<\/td>–<\/td>PAX8<\/td>O<\/td>–<\/td>O<\/td>TSC1<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
DDR2<\/td>O<\/td>–<\/td>–<\/td>IRS1<\/td>O<\/td>–<\/td>–<\/td>PBRM1<\/td>O<\/td>–<\/td>–<\/td>VHL<\/td>O<\/td>–<\/td>–<\/td>\n<\/tr>\n
DICER1<\/td>O<\/td>–<\/td>–<\/td>IRS2<\/td>O<\/td>–<\/td>–<\/td>PDGFRA<\/td>O<\/td>O<\/td>–<\/td>MSI<\/td><\/td><\/td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Horizon Multiplex I cfDNA Reference Standard \ud45c\uc900\ubb3c\uc9c8 20ng \uc0ac\uc6a9\ud558\uc5ec, On target 80% \uc774\uc0c1\uc758 \uc131\ub2a5\uc73c\ub85c \uc8fc\uc694 \ubcc0\uc774\uc5d0 \ub300\ud574 VAF 0.1%\uae4c\uc9c0 \uc548\uc815\uc801\uc73c\ub85c \uac80\ucd9c\ub418\ub294 \uac83\uc744 \ud655\uc778\ud558\uc600\uc73c\uba70, \ub610\ud55c Takara EpiScope\u00ae Methylated HCT116 gDNA \uc640 Takara EpiScope Unmethylated HCT116 DKO gDNA\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc548\uc815\uc801\uc73c\ub85c CpG Methylation \uc815\ubcf4 \ubd84\uc11d\uc774 \uac00\ub2a5\ud558\ub2e4\ub294 \uac83\uc744 \ud655\uc778\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Horizon Multiplex I cfDNA Reference Standard \ud45c\uc900\ubb3c\uc9c8\uc758 8\uac1c \ubcc0\uc774\uac00 \uac80\ucd9c\ub418\ub294\uc9c0 \ubd84\uc11d\ud558\uc600\uc73c\uba70, \ub370\uc774\ud130\ub294 Q30 \uc774\uc0c1 UMI 2\uac1c \uc0ac\uc6a9\ud55c \uc870\uac74\uc73c\ub85c \ub370\uc774\ud130 \ubd84\uc11d \uc9c4\ud589 \/ VAF 1%, VAF 0.1%, WT DNA\uc5d0 \ub300\ud574 \ubd84\uc11d\ud558\uc600\uc73c\uba70, \ud45c\uc900\ubb3c\uc9c8 20ng \uc0ac\uc6a9\ud558\uc5ec, VAF 0.1% \uc774\uc0c1 \uc548\uc815\uc801\uc73c\ub85c \uac80\ucd9c<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\uc0d8\ud50c\uba85 methyl100\uc740 95% \uc774\uc0c1 methylation \ub418\uc5b4 \uc788\ub294 EpiScope\u00ae Methylated HCT116 gDNA\ub97c \uc0ac\uc6a9\ud558\uc600\uc73c\uba70, methyl 0\ub294 \uc800\uba54\ud2f8\ud654\uac00 \uac80\uc99d\ub41c EpiScope Unmethylated HCT116 DKO gDNA\ub97c \uc0ac\uc6a9\ud558\uc600\uace0, methyl 50\uc740 \ub450 \uac00\uc9c0 DNA\ub97c 1:1\ub85c \uc11e\uc5b4\uc11c \ud14c\uc2a4\ud2b8 \uc9c4\ud589<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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cfDNA\uc5d0\uc11c DNA fusion gene\uae4c\uc9c0 \uac80\ucd9c\ud560 \uc218 \uc788\ub294 \ud328\ub110\uc744 \uac1c\ubc1c\ud558\uae30 \uc704\ud574 \ub2e4\uc218\uc758 intron \uc601\uc5ed\uc744 \ud3ec\ud568\ud558\uc5ec \ub514\uc790\uc778\uc744 \uc9c4\ud589\ud558\uc600\uc73c\uba70, off-target \uc704\ud5d8\ub3c4\uac00 \ub192\uc740 \uc601\uc5ed\uc774 \ub2e4\uc218 \uc874\uc7ac\ud588\uc73c\ub098 \ud504\ub85c\ud1a0\ucf5c\uc744 \ucd5c\uc801\ud654\ud55c \uacb0\uacfc on-target \ube44\uc728\uc744 80% \uc774\uc0c1\uc73c\ub85c \ud5a5\uc0c1\uc2dc\ucf30\uace0, \uc704\ud5d8\ub3c4\uac00 \ub192\uc558\ub358 \ub300\ubd80\ubd84\uc758 \uc601\uc5ed\uc5d0\uc11c\ub3c4 \uc548\uc815\uc801\uc778 \ub370\uc774\ud130 \ucee4\ubc84\ub9ac\uc9c0\ub97c \ud655\ubcf4\ud560 \uc218 \uc788\uc74c\uc744 \ud655\uc778<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Twist cfDNA Pan-Cancer Reference Standard (hg38)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Twist cfDNA Pan Cancer Reference Standard \ubb3c\uc9c8\uc758 DNA fusion\uc744 \ubd84\uc11d\ud55c \uacb0\uacfc, 20ng\uc744 \ud22c\uc785\ud588\uc744 \ub54c 1% \uc218\uc900\uc5d0\uc11c\ub3c4 100% \uac80\ucd9c\uc774 \uac00\ub2a5\ud568\uc744 \ud655\uc778<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\ub2e4\uc591\ud55c \uc554 \uc870\uc9c1\uc758 gDNA\uc640 \ud608\uc7a5 \uc720\ub798 cfDNA(1-2ml \ud608\uc7a5 \uae30\uc900 1ng \uc774\uc0c1)\uc5d0\uc11c \uc720\uc804\uccb4(genomic) \ubc0f \ud6c4\uc131\uc720\uc804\uccb4(epigenomic) \ub370\uc774\ud130\ub97c \uc548\uc815\uc801\uc73c\ub85c \ud655\ubcf4\ud558\uc5ec \ubd84\uc11d\uc5d0 \uc801\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. UMI \uc911\ubcf5 \uc81c\uac70(UMI deduplication)\ub97c \ud1b5\ud574 gene panel\uc740 \ucd5c\uc18c 300X, methyl panel\uc740 \ucd5c\uc18c 30X\uc758 \ucee4\ubc84\ub9ac\uc9c0\ub97c \ub2ec\uc131\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/b><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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BeLight\u2122 Pan Cancer Gene and Methylation Panel \uc11c\ube44\uc2a4 \ub77c\uc778\uc5c5<\/b><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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